Neuroimaging indicates the limbic system and hypothalamus as the origin of prodromal symptoms in migraine. This may occur in those with either migraine with aura or migraine without aura. These symptoms may include a wide variety of phenomena, including altered mood, irritability, depression or euphoria, fatigue, craving for certain food(s), stiff muscles (especially in the neck), constipation or diarrhea, and sensitivity to smells or noise. Prodromal or premonitory symptoms occur in about 60% of those with migraines, with an onset that can range from two hours to two days before the start of pain or the aura. These psychiatric disorders are approximately 2–5 times more common in people without aura, and 3–10 times more common in people with aura. Migraine is associated with major depression, bipolar disorder, anxiety disorders, and obsessive–compulsive disorder.
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